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The UW Small Molecule Screening Facility (SMSF) and Medicinal Chemistry Core Facility (MCCF) is a fully equipped high throughput screening facility (HTS) offering expert staff and instrumentation for HTS of over 80,000 small molecules and 20,000 siRNAis. The SMSF also offers custom mechanism of action assays on user provided compounds. The Medicinal Chemistry Core Facility offers consulting, scale-up synthesis, generation of structure activity relationship libraries, natural product fractionation, molecular modeling and compound analytical services.